Uvavanyo olutsha lwe-Hangzhou Luzisa i-Epoch-making Pet Diagnostic New Product-Canine and Feline Renal Function 3-in-1 combo Test Kit
I-Hangzhou New-Test Biotechnology Co., Ltd. ibhengeze ngokusesikweni ukusungulwa kwemveliso ezimbini zokuxilongwa kwezilwanyana zasekhaya ezitsha kwimarike yehlabathi ye-pet immuno-diagnostic: iCanine/Feline renal function Triple Test Kit (Creatinine/SDMA/CysC Triple Test) (Umfanekiso we-1 kunye nomfanekiso we-2), ezisa isisombululo esitsha kunye nesichanekileyo sokuxilongwa kwempilo yezilwanyana kunye nonyango.
Umfanekiso 1 Ikhithi yovavanyo yeCanine renal triple Figure 2 Feline function yerenal triple test kit
Ngo-Okthobha ka-2022, i-New-Test Biotechnology Co., Ltd. yaba yeyokuqala ukuphehlelela i-multi-channel multi-channel multiplex fluorescence immunoassay analyzer, NTIMM4 (isizukulwana sesithathu, bona uMfanekiso 3), kwaye ngo-2024, i-multi-channel multiplex immunofluorescence entsha. i-analyzer, i-NTIMM2 (isizukulwana sesine, jonga uMzobo 4). Umsebenzi wamva nje we-canine / we-feline renal 3-in-1 ikiti yokuvavanya i-combo iyahambelana neemodeli zombini.
Umzobo 3 NTIMM4 Umfanekiso 4 NTIMM2
Ubuchwephesha kuphando lovavanyo lwemolekyuli encinci kunye nophuhliso iminyaka emithandathu, kuqaliswa iimveliso ezintsha.
Ukuchaneka kokufunyanwa kwemolekyuli encinci ibisoloko ingumceli mngeni wokoyisa kwicandelo lovavanyo lwe-POCT, kwaye ikwalisikhokelo sophando kunye nophuhliso apho iNest-Test Bio iye yanikezelwa ukusukela ekusekweni kwayo ngaphezulu kweminyaka emi-6 eyadlulayo. Iimpawu zokucima umzimba kunye nokubola kwezinto zemveli ze-fluorescent zichaphazela ngokuthe ngqo ukuchaneka kweziphumo zokufumanisa i-molecule encinci. Itekhnoloji yokulebula i-nanocrystal enqabileyo yomhlaba, isizukulwana sesine se-fluorescent nanomaterials ephuhliswe yi-New-Test, yamkelwa njengeyona nto izinzileyo ye-nanomaterials ye-fluorescent kwimarike, enenzuzo yokoyisa iimpawu zomzimba zokucima ukukhanya. Idityaniswe neminyaka eliqela yokuqhubela phambili inkqubo, ekugqibeleni iyisombulule ingxaki yehlabathi yokuchaneka kakubi kuvavanyo lwe-POCT encinci ye-molecule. Utyhala lokuqala yikiti yokuvavanya ukusebenza kwezintso kathathu. Iqinisekisa ukuchaneka kunye nokuzinza kwee-athomu ezimbini ezincinci (i-creatinine & SDMA) i-reagents yokufumanisa i-reagents ngaphakathi kwe-2 iminyaka yokuqinisekisa.
“Uvavanyo olunye lukwakhona, kutheni ke kuphuhliswe i-renal function triad”——Imvelaphi yokwenziwa komsebenzi wezintso ezintathu
Okwangoku, izibonakaliso eziqhelekileyo zokusebenza kwezintso ezingaqhelekanga kwizinja kunye neekati ziquka i-creatinine (CREA) kunye ne-urea nitrogen kwi-biochemistry; I-CysC (i-cystatin C) kunye ne-symmetric dimethylarginine (i-SDMA) kwiimpawu zokugonywa, njl njl. Okwangoku, kukholelwa ngokubanzi ukuba zonke izikhombisi ezikhankanywe ngasentla zihluzwa nge-glomerulus. Xa izinga lokuhluza i-glomerular liyancipha ngenxa yokwenzakala kwezintso, ezi zalathisi ziya kuqokelelana egazini kwaye zonyuke ekugxininiseni, ngaloo ndlela zibonisa iqondo lokungasebenzi kakuhle kwezintso. I-International Society for Research in Kidney Diseases (IRIS) inkqubo yokuhlela ihlela ukukhubazeka kwezintso kwiikati zibe ngamabakala amane ngokusekelwe kwixabiso le-creatinine (iBakala I, eliqhelekileyo okanye eliphakathi: <1.6 mg/dL; iBakala II, eliphakathi: 1.6-2.8 mg / dL; iBanga le-III, elinzima: 2.8-5.0 mg / dL; mg/dL).
Ukukhubazeka kwezintso kwizinja kuhlelwe ngamabakala amane (iBakala I, eliqhelekileyo okanye eliphakathi: <1.4 mg/dL: IBakala II, imodareyitha: 1.4-2.0 mg/dL: IBakala III, elinzima: 2.0-4.0 mg/dL: IBakala IV, kunye nenqanaba lokugqibela:> 4.0 mg / dL). Nangona kunjalo, ngenxa yobuthathaka obuncinci be-creatinine kwisifo sezintso ezingapheliyo (CKD), enye isalathisi sangaphambili se-nephron function filtration, "symmetric dimethylarginine (SDMA)", yasetyenziswa. Ngokwedatha, i-SDMA ingabonisa ukungaqhelekanga kwi-25-40% yokukhubazeka kwezintso, ngelixa i-creatinine idla ngokuthathwa njengento engaqhelekanga kwi-75% yokukhubazeka.
I-CysC (i-cystatin C) i-cysteine protease inhibitor, i-molecular weight low (13.3 kD), i-protein esisiseko ye-non-glycosylated. Lelinye lawona manqaku asetyenziswa kakhulu okusebenza kwangoko kwezintso kumayeza omntu. Njenge-creatinine kunye ne-SDMA, ihluzwa nge-glomerulus, kodwa iyahluka kwi-creatinine kunye ne-SDMA ngokuba imetabolism yayo ayisebenzisi i-urinary tract, kodwa iphantse yachithwa ngokupheleleyo ngokuphinda ifakwe kwii-tubules ze-renal. ayizange ibonwe ngaphambili, ikhokelela abaphengululi abaninzi, iingcali kunye noncwadi kwizigqibo ezibini ezihlukeneyo malunga nokulimala kwezintso ezingapheliyo kwiikati: abanye bakholelwa ukuba iCysC umakisha kwangoko wokwenzakala okungapheliyo kwezintso ezinokuthi zisetyenziswe kuzo zombini izinja kunye neekati, ngelixa abanye bakholelwa ukuba i-CysC ihambelana ngokuphakathi kakuhle kwi-canine CKD, kodwa kakubi kwiikati.
Kutheni le nto kukho izigqibo ezibini ezichaseneyo kwisalathiso somsebenzi wokucoca iglomerular?
Isizathu yi-Anuria, yimeko exhaphake kakhulu kwiikati kunezinye iintlobo, ngakumbi kwiikati zamadoda. Ezinye iinkcukacha zibonisa ukuba iziganeko ze-Anuria kwiikati zamadoda ziphezulu njenge-68.6%, kwaye i-Anuria iya kubangela ngokuthe ngqo ukuthintela ukukhutshwa kwe-creatinine, igazi le-urea nitrogen kunye ne-SDMA. I-organism isoloko i-metabolizing kwaye ivelisa i-creatinine entsha, i-blood urea nitrogen kunye ne-SDMA, xa ibona zonke izibonakaliso ezintathu egazini ngeli xesha, kuya kubakho ukunyuka okubukhali okanye ukuqhuma kwezibonakaliso kungakhathaliseki ukuba i-glomerulus yonakaliswe ngokwenene.
I-CysC inexabiso layo elikhethekileyo ngeli xesha, nangona esi sibonakaliso sihluzo lwe-glomerular, aluyiyo i-metabolized ngumchamo, luhamba nge-tubular yokubuyisela kwakhona. Xa i-Anuria isenzeka kodwa umsebenzi wezintso uqhelekile, isalathisi seCysC sisenokugcinwa kwinqanaba eliqhelekileyo. Kuphela xa i-glomerulus okanye umonakalo we-tubular wenzeka ngokwenene, isalathisi se-CysC siya kunyuswa ukuba singaqhelekanga. Ke ngoko, ukubonwa kwazo zontathu izalathisi kunokwenza uxilongo oluchanekileyo kwaye kubonelele ngonyango oluhambelanayo ngokukhawuleza nangempumelelo.
Uvavanyo olutsha lokumakisha umsebenzi wezintso 3-in-1 iikhithi zovavanyo zinika ukubaluleka okutsha kwezonyango ekubhaqweni kokwenzakala kwezintso ezinjeni nasezikatini!
Ukucacisa imigaqo kunye nokudibanisa kunye neempawu zezibonakaliso, i-New-Test renal function marker 3-in-1 izixhobo zokuvavanya zazalwa ngokubaluleka okubalulekileyo kwekliniki kwizinja kunye neekati (ingakumbi iikati) kunye ne-Anuria:
I-New-Test renal function marker i-3-in-1 iikiti zokuvavanya zisetyenziselwa ukwahlula ukuba kukho ukwenzakala kwangempela kwe-renal kwi-Anuria okanye kubangele ukukhutshwa kwe-indexes ngenxa ye-Anuria. Ukwenzakala okusebenzayo kwezintso kufuna kuphela i-catheterization ye-urinary kunye nokhathalelo oluhambelanayo, kwaye i-prognosis ingcono ngokubanzi. Ukuphakama koxinzelelo lwezalathisi kufuna kungekuphela nje i-catheterization yomchamo kunye nonyango oluchasene nokudumba, kodwa kunye nonyango olunxulumene nesifo sezintso, kwaye uqikelelo luyinkathazo, kwaye kunokwenzeka ukuba luguquke lube sisifo sezintso.
Apha ngezantsi kukho i-New-Test renal function marker 3-in-1 data kits test ye-Anuria (ukwenzakala okungeyiyo yokwenyani yezintso) kunye ne-Anuria + ukonzakala kwezintso kuVavanyo olutsha lweemeko zophando lweklinikhi:
| Ukufunyanwa kweAnuria Uvavanyo olutsha lokumakisha umsebenzi wezintso 3-in-1 iikhithi zovavanyo | Iprojekthi | Isiphumo | Isiphumo |
| I-Creatinine | + | + | |
| I-SDMA | + | + | |
| CysC | + | - | |
| Ukuqukumbela | I-Anuria ibangele ukulimala kwezintso | Inqanaba lokuqala le-Anuria kunye nokulimala kwezintso okanye i-Anuria engekafikeleli kwingozi yezintso |
Apha ngezantsi yinxalenye yedatha yeklinikhi eqhelekileyo kunye nenkcazo yemeko yovavanyo olutsha lomsebenzi wezintso 3-in-1 izixhobo zovavanyo:
| Ikati | Imbali yezoNyango | Uphawu lwezonyango | CysC(mg/L) | I-SDHA (ug/dL) | I-CR(mg/dL) | Ukuqukumbela |
| 2024090902 | Cystitis/ Ukwenzakala ezintso | Isimo sengqondo esibi, Ukuphelelwa ngumdla, Isalathisi esingaqhelekanga sezintso, iAnuria (Ukungaphumeleli kwezintso okungapheliyo, i-anuria) | 1.09 | 86.47 | 8.18 | Ukwenzakala kwezintso kunye ne-Anuria |
| 2024091201 | / | Isimo sengqondo esibi, i-Anuria, umsebenzi wezintso ongaqhelekanga | 0.51 | 27.44 | 8.21 | Akukho kwenzakala ezintso ngeAnuria/Early stage |
| 2024092702 | / | Anuria | 0.31 | >100.00 | 9.04 | Akukho kwenzakala ezintso ngeAnuria/Early stage |
| 2024103101 | / | Anuria | 0.3 | 14.11 | 6.52 | Akukho kwenzakala ezintso ngeAnuria/Early stage |
| 2024112712 | Anuria | 0.5 | >100.00 | 8.85 | Akukho kwenzakala ezintso ngeAnuria/Early stage | |
| 2024112601 | Dysuria / Anuria | 0.43 | >100.00 | 9.06 | Akukho kwenzakala ezintso ngeAnuria/Early stage | |
| 0.47 | >100.00 | 878 | Akukho kwenzakala ezintso ngeAnuria/Early stage | |||
| 2024112712 | / | Anuria | 0.54 | 94.03 | 8.64 | Akukho kwenzakala ezintso ngeAnuria/Early stage |
Kwimeko ye-Anuria, ngenxa yokungafani kwindlela yangaphakathi ye-metabolism yesalathisi ngasinye, kuya kubakho ukungafani okukhulu kwi-filtration index ye-renal function. Ngoko ke, ulwahlulo oluqhelekileyo lokulimala kwe-renal ye-creatinine okanye i-SDMA ayisasebenzi, kwaye isiphelo sekliniki esisondeleyo sinokufumaneka kuphela ngokudibanisa uhlalutyo kunye nesinye isalathisi "CysC". Kucetyiswa ukuba iilabhoratri (izibhedlele) ziseke imigangatho yangaphakathi esekelwe kumava ezonyango, ukuze kuphononongwe ngakumbi kunye nokubaluleka kweklinikhi entsha.
Ekugqibeleni, i-New-Test Biotech inethemba lokuba eli nqaku liza kuphosa isitena ukutsala i-jade, kwaye sinethemba lokuba amachiza amaninzi ezilwanyana zaseTshayina kunye nabavelisi be-reagent yokuxilonga baya kuphuhlisa iimveliso ezibalulekileyo zeklinikhi kwaye bancedise oogqirha bezilwanyana basekhaya ukuba bafikelele kwinqanaba eliphezulu ihlabathi!
Isihlomelo: Ukwamkelwa kweSicelo sePatent soKhuseleko lwePropati yoBukrelekrele
Ixesha lokuposa: Jan-22-2025
